Only select registry of toxic effects of chemical substances rtecs data is presented here. The information included in this section describes the potential hazards of the individual ingredients. Cisplatin 1 mgml sterile concentrate should be diluted in 2 litres of 0. Jun 01, 2015 cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin.
Platinumii diammine dichloride, cisplatin synonyms. Mar 01, 2019 cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. Find documents on drug safety and administration for healthcare providers, including calculations. We work hard to ensure that we are fully uptodate with regulations, and make sure to incorporate changes as soon as they occur, so that you do not risk having outofdate safety data sheets. During all fire fighting activities, wear appropriate protective equipment, including self contained breathing apparatus. H300, h318, h350 for the full text of the h statements mentioned in this section, see section 16. Nov 20, 2012 cisplatin cisdiamminedichloroplatinum, cispt is a nonorganic complex, where the central atom is divalent platinum.
Cisplatin dosing, indications, interactions, adverse. Anderson cancer center, 1515 holcombe boulevard, houston, tx 770304009, usa cisplatin is one of the most potent antitumor agents. The following side effects are common occurring in greater than 30% for patients taking cisplatin. Cytotoxic evaluation of cisplatin, cisplatinhydroxypropyl.
The drug is also sometimes used offlabel to treat head and neck cancers. Incidence of cisplatin induced ototoxicity in adults with. Cisplatin is used together with other medications to treat bladder cancer, testicular cancer, or ovarian cancer. Identification of the substancepreparation and the companyundertaking material name. Cisplatin cas 15663271, is a platinum coordination complex with potent antineoplastic activity. Cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Several payment sources exist for cancer drugs in ontario, depending on the drug, disease indication, and how and where it is delivered. Formation of toxic gases is possible during heating or fire. There is no relationship between the presence or severity of cisplatin side effects and effectiveness of cisplatin.
Cisplatin side effects, dosage, interactions drugs. A study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin. Cisplatin offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. The use of cisplatin in patients with preexisting kidney dysfunction and the renal effects of the platinum analogs, carboplatin and oxaliplatin, are discussed elsewhere. Cisplatin 1 mgml sterile concentrate summary of product. Hazardous ingredient ww% cas number pinumber 1017 manufacturers name chemco manufacturing. Cisplatin may give allergic reactions in some patients. Pharmaceutical division cisplatin injection safety data sheet sds effective date. Cisplatin is a medicine used alone or with other therapies to treat cancer of the testicles, ovaries, or bladder. Cisplatin was discovered in 1845 by michele peyrone but its biological property was hidden until 1965 when a.
Original vials of cisplatin injection 1 mgml, teva were stored at room temperature. Each 50 ml, 100 ml or 200 ml amber vial of cisplatin injection contains. Introduction cisdiaminedichloroplatinum ii cisplatin is a major antineoplastic drug widely used in the treatment of several malignancies1,2. Cisplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. Many people living with cancer experience nausea, diarrhea and other symptoms from their treatment or disease. Before research use of highly toxic chemicals, please complete this form and have it approved by your supervisor. Mechanism of action cisplatin is believed to kill cancer cells by binding to dna and interfering with its repair mechanism, eventually leading to cell death. May 28, 2019 hypersensitivity to cisplatin or to any of the excipients listed in section 6.
Sep 05, 2014 register now and get a free online msds binder. Cisplatin cisplatin dose, indications, adverse effects. These cotton glove samples were then analyzed for cisplatin. Sigmaaldrich offers a number of cisplatin products.
Cisplatin is one of the best and first metalbased chemotherapeutic drugs see fig. Cisplatin can cause severe bone marrow suppression with fatalities due to infection. Safe handling of hazardous chemotherapy drugs in limited. Monitor complete blood counts before initiating therapy, prior to each new cycle, and as clinically indicated. Cisplatin dosing, indications, interactions, adverse effects. Cytotoxic evaluation of cisplatin, cisplatinhydroxypropyl b.
Cisplatin cas 15663271 scbt santa cruz biotechnology. The antineoplastic activity of the compound is conditioned by the spatial layout of chlorine atoms in cis position. To elucidate the incidence of cisplatin induced ototoxicity in adult patients, with a focus on an adult population. These solutions are stable up to 24 hours at room temperature. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. Show this safety data sheet to the doctor in attendance. This information was last updated on september 5, 2003. Cisplatin injection is a clear, colorless, sterile aqueous solution. The first metal based anticancer drug sciencedirect.
Accelio present applied technology created and tested using. Platinol cisplatin for injection side effects, images, uses. We took wipe samples and area and personal breathing zone air samples for cisplatin. Cspm2 hydration protocol for cisplatin chemotherapy. May use concomitant amifostine to decrease nephrotoxicity.
It has been widely accepted because of its potent cytotoxic effects on a variety of tumor types including testicular, ovarian, and cervical carcinoma3. Platinol cisplatin for injection, usp should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Cisplatin investigated as a drug, mutagen, natural product, reproductive effector, and tumorigen. The molecular formula of cisplatin is cl2h6n2pt mw 300. Carboplatin therapy is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent liver injury. Cisplatin is compatible in solutions containing an adequate amount of chloride ions and is incompatible with solutions having low concentrations of these ions. See chemotherapy nephrotoxicity and dose modification in patients with kidney impairment. Higher doses of cisplatin are being given in daycare, increasing the strain on the chemotherapy suites and pharmacy. What niosh did we evaluated the facility on may 1112, 2009. Dec 31, 2019 cisplatin injection is a clear, colorless, sterile aqueous solution. In order to for patients to be treated as a day case, the regimens have been modified as follows. Accidental release measures contain spill and collect, as appropriate. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers.
Should be administered only by or under the direct supervision of a qualified physician who is experienced in the use of cancer chemotherapeutic agents. Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride, usp, and 500 mg mannitol, usp. Ciswel, cisplatin injection, cisplatin manufacturer, cisplatin manufacturer in india, cisplatin price in india, cisplatin cost in india, cisplatin cost effective option,cisplatin msds created date. As is discussed at length in other contributions to. Quantification of cisplatin, carboplatin and oxaliplatin in spiked human plasma samples by icpsfms and hydrophilic interaction liquid chromatography hilic combined with icpms detection. No cisplatin was detected in any ga air samples mdc 0.
Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Pdf bookmark sample page 1 of 4 pdf bookmark sample sample date. Online idms was applied for accurate, species unspecific quantification. The disproportionate accumulation of cisplatin in kidney tissue contributes to cisplatin induced nephrotoxicity. Do not handle until all safety precautions have been read and understood. Inclusion criteria were 1 cisplatin as the primary chemotherapeutic agent and 2 hearing evaluation performed prior. What is cisplatin platinol, platinol restricted access, platinolaq. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. Each 50 ml or 100 ml amber vial of infusion concentrate contains. Sds of cisplatin, safety data sheets, cas 15663271 chemblink. You have selected the maximum number of product attributes 3 to compare. Peyrone in 1844 and its chemical structure was first elucidated by. Jul 18, 2017 cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. Use is contraindicated in those patients with a history of allergic reaction to cisplatin or other platinum containing compounds, or any component of the formulation.
Cisplatin, mono and diaquacisplatin were measured in aquatic samples and in diluted urine of a cancer patient by hplcicpms. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. The active ingredient, cisplatin, is a yellow to orange crystalline powder with the molecular formula ptcl. Peyrone in 1844 and its chemical structure was first elucidated by alfred werner in 1893. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctors office. All testing was performed using 316 stainless steel as the substrate surface. Cisplatin fda prescribing information, side effects and uses. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. The physical and chemical stability of cisplatin teva in.
The antitumor properties of platinumcontaining drugs are attributable in large measure to the kinetics of their ligand displacement reactions. There are many options to help minimize or prevent the side effects of cisplatin. The cisplatin concentration in proximal tubular epithelial cells is about 5 times the serum concentration. Sheet provided by the manufacturer that summarizes the chemical prop. Examples safety data sheet sds msds here you can see examples of safety data sheets in some of the various languages we handle.
Induces apoptosis in cancer cells, possibly via caspase3 activation. Evaluation of exposures to healthcare personnel from. Cisplatin hydration for outpatients chemotherapy regimen. Immediately flush eyes with plenty of water for at least 15 to 20 minutes. Other companies are charging thousands of dollars to set up accounts and give you access to their msds. The first step in the process after the cisplatin molecule penetrates the cell membrane intact is for a molecule of water to. The cleaning protocol that consists of peridox rtu cleaner and 70% ipa isopropyl alcohol prewetted wipers has shown to remove at least 99.
Platinol cisplatin for injection side effects, images. Appropriate management of therapy and complications is. Mar 06, 2018 what is cisplatin platinol, platinol restricted access, platinolaq. The spectrum shows three maxima at 203 nm, 301 nm, and 362 nm, a shoulder at 285 nm, and minima at 246 nm and 348 nm. Cisplatin is generally synthesised by the ammonolysis of potassium tetrachloroplatinate k 2 ptc1 4. Overview this sample consists of a simple form containing four distinct fields. The disproportionate accumulation of cisplatin in kidney tissue contributes to. Cisplatin injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Forms inter and intrastrand dna adductscrosslinks, consequently blocking dna replication and transcription and inducing cell death 2, 12, 15. Read complete cisplatin msds ciswel manufactured by getwell oncology a leader manufacturing complex oncology generics in india.
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